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Dené C. Wrenn, MD, OHC Gynecologic Oncologist

Dené C. Wrenn, M.D.

Dr. Wrenn’s specialties include risk-reducing surgery and new treatments for gynecologic malignancies, including robot-assisted surgery. “With gynecologic oncology, I have the opportunity to treat cancer surgically and medically, while providing compassionate care and understanding.”
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Gynecologic Oncology




or call


Gynecologic malignancies
Minimally invasive, risk-reducing surgery


Novel treatments for gynecologic malignancies


Spending time with friends and family


Tulane University School of Medicine


Medical University of South Carolina


Jackson Memorial Hospital


Board Certified in Gynecologic Oncology, American Board of Obstetrics and Gynecology
Medical License and DEA, Florida and Ohio


American College of Obstetrics and Gynecology
The Gynecology Oncology Society (THEGOS)
Society of Gynecologic Oncologists


Southeastern Fertility Stork Award, Medical University of South Carolina; for outstanding care and compassion to women seeking pregnancy
J. Marion Sims Award, Medical University of South Carolina; for surgical excellence in minimally invasive surgery, gynecology, and gynecologic oncology

Wrenn DC, Saigal K, Lucci JA, Pearson MJ, Simpkins F, Schuman S, Twiggs LB, Walker GR, Wolfson AH. A Phase I Study using low-dose Fractionated whole abdominal radiotherapy as a Chemopotentiator to full-dose cisplatin for optimaly debulked stage III/IV carcinoma of the endometrium. Gynecol Oncol. 2011 Jul; 122 (1):59-63. PMID: 21474169.

Ianosi-Irmie M, Vu H, Whitbred JM, Pridjian CA, Nadig JD, Williams MY, Wrenn DC, Pridjian G, Puschett JB. A Rat Model of Pre-eclamplsia. Clin Exp Hypertens. 2005 Nov; 27 (8):605-17. PMID: 16303637


Dauphin-Mckenzie N, Pasternak M, Diaz J, English D, Lambrou N, Pearson J, Wrenn D, Schuman S, Simpkins F, Lucci III J. “Outcome of Patients with FIGO Stage IB2 treated with Radical Hysterectomy Before and After the Era of Adjuvant Chemoradiation for High and Intermediate Risk Factors: 20 years of a Single-Institution Experience. Society of Gynecologic Oncology Annual Meeting, Austin, TX. March 2012; William A. Little Society Annual Meeting, Fort Lauderdale, FL. April 2012.

Wrenn D, Dauphin-Mckenzie N, Beninati M, Schroeder E, Pearson J,
Schuman S, Simpkins F, Diaz J, Twiggs L, Lucci III J. Evaluation of Gemcitabine plus Docetaxel (days 1 and 15) without granulocyte growth factor support for treatment of uterine leiomyosarcoma William A. Little Society Annual Meeting, Fort Lauderdale, FL. April 2012.

Schroeder E, Burbano-Levy X, de la Garza J, Wrenn D, Mckenzie N, Lucci III J, Diaz J. A Cost Effectiveness Analysis of the Treatment of Advanced Epithelial Ovarian Carcinoma. William A. Little Society Annual Meeting, Fort Lauderdale, FL. April 2012.

Dauphin-McKenzie N, Hnatyszyn J, Prewitt J, Ganjei-Azar P, Morishita A, Guetouche T, Potter J, Wrenn D, Pearson JM, Lucci 3rd.  Non-16 and 18 HPV Types are More Prevalent in HIV-infected Women with CINIII. Society of Gynecological Oncology Annual Meeting. San Francisco, CA. March 12-17, 2010.

Wrenn D, Wolfson A, Saigal K, Walker G, Nishida K, Twiggs L, Pearson J, Simpkins F, Lucci J. A Phase I Study Using Low-Dose Whole Abdominal Radiotherapy as a Cisplatin Chemosensitizer for Optimally Debulked Stage III/IV Carcinoma of the Endometrium. Society of Gynecological Oncology Annual Meeting. San Francisco, CA. March 12-17, 2010.

Mckenzie N, Kobetz E, Reis I, Duncan R, Zhao W, Rosa-Cunha I, Jimenez E, Papadia A, Wrenn D, Schuman S, Nishida K, Simpkins F, Pearson M, Twiggs L, Lucci J. The Association between use of HIV Protease Inhibitors and Regression of Cervical Dysplasia. Eurogin International Meeting. Monte-Carlo, Monaco. February 17-20, 2010.

As a member of our OHC physician team, Dr. Wrenn has full access to the OHC Clinical Trial research program.

We encourage our patients to discuss all of their healthcare options — including Clinical Trial research programs — with their doctor.

The following are recent reviews provided by actual OHC patients:

"I just love Dr. Dené Wrenn; she was very personable and kind. I am really scared of my upcoming surgery and she was very down to earth with me and used terms I could understand, which most doctors don't do. I feel much better since I met Dr. Wrenn. I would totally refer others to her if needed."

"Dr. Wrenn is very good at answering all questions and makes sure that you feel comfortable."

"Dr. Dené Wrenn is an extremely compassionate, competent and truly wonderful professional. I was thankfully referred to her when ovarian cysts were found to be potentially pre-cancerous. I was obviously frightened at the potential prognosis. Dr. Wrenn immediately put my fears to rest, with her unbelievable listening skills and ability to truly connect with me on a personal level. From our initial visit to post-surgery, she has kept me well informed of all medical issues, thoroughly explaining everything in an easily understood manner. I highly recommend Dr. Wrenn; I only wish she could be my general practitioner. I would be happy to speak with any potential patients, praising her for her calm personality and her superb medical skills."