The Latest News in Cancer Research
With the tri-state’s largest independent clinical research department, OHC is well on top of the latest cancer news around the world — even while we’re creating our own. But we know you’re not able to spend all day, every day, learning about the latest cancer developments like we do. So we’d like to share excerpts from some of the news items that recently caught our attention. We’ll try to give you a similar briefing every month or so.
Protein Antibody May Be New Way to Treat Solid Tumors
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects.
The researchers from Monash University and Ludwig Cancer Research, in Australia, and KaloBios Pharmaceuticals, in the US, have had their findings published in the journal Cancer Research. “We screened various tumors from patient biopsies – sarcomas, melanomas as well as prostate, colon, breast, brain and lung cancers – and confirmed EphA3 expression on stromal cells and newly forming blood vessels,” said Professor Andrew Scott, from Ludwig Cancer Research. Read full story at Science Daily
Aspirin May Help Reduce Breast Cancer Rate
Researchers at the University of Texas in Austin have found that regulary taking aspirin (or other nosteroidal anti-inflammatory drucks called NSAIDs) may reduce the rate of breast cancer recurrence by half in obese women. The researchers followed 440 breast cancer survivors — most of them past menopause and overweight or obese — who were diagnosed between 1987 and 2011. The women had estrogen receptor-positive breast cancer, which requires the hormone estrogen to grow. “Twelve percent of those not taking NSAIDs had a recurrence, but 6 percent of those taking the drugs did,” said study author Linda deGraffenried, associate professor of nutritional sciences. Read full story at CBS News
Study Reveals One Reason Why Brain Tumors More Common in Men
New research at Washington University School of Medicine in St. Louis helps explain why brain tumors occur more often in males and frequently are more harmful than similar tumors in females. For example, glioblastomas, the most common malignant brain tumors, are diagnosed twice as often in males, who suffer greater cognitive impairments than females and do not survive as long. The complete study appeared in the Aug. 1 issue of The Journal of Clinical Investigation. Read full story at Washington University in St. Louis
Mechanism Identified Which Halts Progression of Abnormal Cells into Cancer
The Hippo pathway (a tumor suppressor pathway) is responsible for sensing abnormal chromosome numbers in cells and triggering “cell cycle arrest,” which prevents progression into cancer. The research was conducted by Boston University School of Medicine. Although we already understand the link between abnormal cells and tumor suppressor pathways, cancer researchers have not understood the critical steps in between. The complete study appears in the recent issue of Cell. Read full story at Science Daily